Rheumatology

NSAIDs: Are They All the Same?

February 1, 2018
NSAIDs: Are They All the Same?

By Vishal Shah, MD

Peer Reviewed

Nonsteroidal antiinflammatory drugs (NSAIDs) are a heterogenous group of non-opioid analgesics and anti-inflammatory agents. Their use is ubiquitous, from treating a simple tension headache to a sprained ankle. NSAIDs are available over the counter and in prescription form.

NSAID use in the United States is rising; from 2005 to 2010, prescriptions for NSAIDs increased by 41%.1 These numbers will continue to rise with the increasing population age and subsequent demand for analgesics to treat conditions related to increasing age …

Read more »

Age Is Just a Number: Combating Muscle Loss in The Elderly

December 14, 2017
Age Is Just a Number: Combating Muscle Loss in The Elderly

By Carl Preiksaitis

Peer Reviewed

The term “sarcopenia” was introduced in 1989 to characterize the loss of muscle mass that occurs as a consequence of advancing age.1 Use of the term has since grown to include the loss of muscular function experienced in older adults. The prevalence of sarcopenia is estimated to be approximately 29% in community-dwelling older adults and 33% in individuals living in long-term care institutions. Sarcopenia is linked to increased morbidity and mortality from physical disability, increased falls and fractures, decreased quality …

Read more »

Diagnostic Dilemma-Poststreptococcal Reactive Arthritis in a Pregnant Woman

September 18, 2013
Diagnostic Dilemma-Poststreptococcal Reactive Arthritis in a Pregnant Woman

By Bryan Stierman and Todd Cutler, MD

Faculty Peer Reviewed

Case Presentation

A 35-year-old Hispanic woman presented to the emergency room with severe joint pain and swelling for one week.

The patient had a history of hypothyroidism and hepatitis C which was treated with interferon therapy two years prior. She was recently discovered to be pregnant and, at the time of presentation, was in her tenth week of pregnancy. Three weeks prior to admission she developed a sore throat. She saw an outside care provider …

Read more »

Gout: A Disease of the Blessed or a Blessing in Disguise?

June 8, 2012
Gout: A Disease of the Blessed or a Blessing in Disguise?

By Krithiga Sekar

Faculty Peer Reviewed

“The patient goes to bed and sleeps quietly until about two in the morning when he is awakened by a pain which usually seizes the great toe, but sometimes the heel, the calf of the leg or the ankle… so exquisitely painful as not to endure the weight of the clothes nor the shaking of the room from a person walking briskly therein.”

—Thomas Sydenham  (1683)

Gout, an excruciatingly painful but relatively benign form of arthritis in the modern …

Read more »

FROM THE ARCHIVES: How Do You Diagnose Polymyalgia Rheumatica?

March 1, 2012
FROM THE ARCHIVES: How Do You Diagnose Polymyalgia Rheumatica?

Please enjoy this post from the archives dated August 12, 2009

By Eve Wadsworth MD

Faculty Peer Reviewed

Polymyalgia rheumatica (PMR) is a condition that resembles several different disorders including osteoarthritis and can be difficult to diagnose. In addition to osteoarthritis, PMR can resemble conditions as diverse as depression, fibromyalgia, myopathic drug reactions, and malignancy. PMR, however, can be associated with dangerous consequences, namely blindness, and is responsive to well-established treatment regimens. As such, familiarity with PMR’s presentation and its unique features is critical so …

Read more »

Systemic Lupus Erythematosus and Premature Coronary Artery Disease

July 14, 2011
Systemic Lupus Erythematosus and Premature Coronary Artery Disease

Please enjoy this post from the Clinical Correlations archives first posted June 17, 2009

Ishmeal  Bradley MD

Faculty Peer Reviewed

Ms. W is a 35 yo woman with a history of systemic lupus erythematosus diagnosed 10 years ago. Her only medications are hydroxychloroquine and prednisone for occasional disease flares. She is otherwise healthy. She has no known personal or family history of cardiac disease or stroke, but does smoke ½ pack of cigarettes per day. Currently, she denies any chest pain, shortness of breath, urinary …

Read more »

ANCA and Small-Vessel Vasculitis

July 7, 2011
ANCA and Small-Vessel Vasculitis

By Eugene Friedman, Class of 2012

Faculty Peer Reviewed

The discovery of anti-neutrophil cytoplasmic antibodies (ANCA) was a serendipitous finding. In 1982, Davies and colleagues published a report detailing their discovery of antibodies that specifically localized to the cytoplasm of neutrophils in patients with necrotizing glomerulonephritis and small-vessel vasculitis–antibodies that disappeared after immunosuppressive therapy and reappeared with disease recurrence. Two years later, Hall and colleagues confirmed this observation , paving the way for the 1985 Lancet article where van der Woude and colleagues proposed …

Read more »

From the Archives: Myths and Realities: Does the Weather Really Affect Arthritis?

March 3, 2011
From the Archives: Myths and Realities: Does the Weather Really Affect Arthritis?

Please enjoy this post from the Clinical Correlations archives first posted March 19, 2009

Aditya Mattoo MD

Faculty Peer Reviewed

For our first post, I wanted to address the age old belief that changes in the weather can affect arthritis pain. Since the time of Hippocrates, who wrote about the effects of hot and cold winds on people’s health, this topic has been debated. Even Osler suggested in 1892 that arthritis sufferers of wealth vacation in the south to avoid the cold damp weather of …

Read more »