Breaking News

New National Network E-mails Drug Alerts Instantly to U.S. Doctors

July 31, 2008
New National Network E-mails Drug Alerts Instantly to U.S. Doctors

Commentary by Marilena S. Antonopoulos Pharm.D, Pharmacology Section Editor

Until recently, drugs safety alerts (aka “Dear Doctor letters”) were sent out to physicians through traditional U.S. mail, a slow and error-prone process. These alerts can be significantly delayed and may not even reach the intended recipient. In an effort to improve the speed and efficacy of the delivery of FDA mandated patient safety alerts to physicians and other healthcare providers, the Health Care Notification Network (HCNN) has announced the launching of its online service that …

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Breaking news: FDA issues new Boxed Warning for Fluoroquinolones

July 10, 2008
Breaking news: FDA issues new Boxed Warning for Fluoroquinolones

Commentary by Marilena S. Antonopoulos, PharmD, Pharmacology Editor

On July 8th, the FDA notified the manufacturers of fluoroquinolone antimicrobial drugs that a Boxed Warning in the product labeling and a Medication Guide for patients concerning the increased risk of tendinitis and tendon rupture is necessary. The FDA conducted a new analysis of the available literature and post-marketing adverse event reports which reconfirms that the use of fluoroquinolones is associated with an increased risk of tendon rupture.

The risk of developing fluoroquinolone-associated tendinitis and tendon rupture …

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Welcome to Clinical Correlations 2.0

July 1, 2008
Welcome to Clinical Correlations 2.0

317 posts, 67,000 unique visitors from 167 different countries and almost 100,000 hits later and we’re still here. It’s time we evolved…

Welcome to Clinical Correlations Version 2.0. What better day than July 1st, the start of the academic year to celebrate our success with a total redesign of our site. Our new tagline says it all: “A Daily Dose of Medicine.” We are looking to be your destination on the internet to receive a morsel of internal medicine wisdom every day.

Click around and …

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Some say tomato, some say nationwide outbreak of Samonellosis

June 10, 2008
Some say tomato, some say nationwide outbreak of Samonellosis

Commentary by Chirayu Gor, MD

The CDC has issued an alert regarding the outbreak of a rare type of Salmonella, termed Salmonella Saintpaul. Since mid-April, over 140 persons have been identified in 16 states with this uncommon serotype of Salmonella. Preliminary investigation has implicated tomatoes.…

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Measles Alert!

February 20, 2008
Measles Alert!

Commentary by Rosemary Adamson MD, PGY-2

Be on the look-out for measles! New York City’s Department of Health and Mental Hygiene (DOHMH) issued a measles alert at the end of last November because there were 5 confirmed cases of measles being imported from abroad in 2007 to NYC. The DOHMH wished to raise healthcare provider awareness of measles, especially in travelers. Coming from the UK, this alert is close to my heart, as Britain has been battling with reduced uptake of the MMR vaccine and …

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A New Path for the ACCORD (The Action to Control Cardiovascular Risk in Diabetes) trial: Does Being Sweeter Save Lives?

February 8, 2008
A New Path for the ACCORD (The Action to Control Cardiovascular Risk in Diabetes) trial: Does Being Sweeter Save Lives?

Commentary by Melissa Freeman MD, Endocrinology Section Editor

The ACCORD trial is an ongoing 5-year, North American, randomized study that began in 2001 to evaluate potential interventions to decrease cardiovascular (CV) events in adults living with DM2.  The trial enrolled 10,251 adults, aged 40- 82, with DM2 for 10 or more years, and a history of CV disease or two CV risk factors in addition to DM2. All participants were randomized at enrollment into intensive versus standard glucose control. In addition, participants were also enrolled …

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Breaking News: A Disappointment for Zetia

January 15, 2008
Breaking News: A Disappointment for Zetia

Commentary by Alana Choy-Shan MD, NYU Chief Resident

The highly anticipated results of the ENHANCE trial will likely be presented at the American College of Cardiology meeting in March, but the preliminary results already have everyone talking. ENHANCE was a multinational, double-blind randomized controlled trial sponsored by Merck and Schering-Plough (the manufacturers of the combination ezetimibe/simvastatin pill). A total of 720 patients who were heterozygotes for Familial Hypercholesterolemia were randomized to treatment with either ezetimibe/simvastatin 10/80mg or simvastatin 80mg. The primary endpoint was change in …

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Breaking News: FDA Issues New Warnings for Haldol

September 21, 2007
Breaking News: FDA Issues New Warnings for Haldol

Commentary by Helen Kourlas, PharmD

On September 17th 2007, the FDA issued an advisory warning healthcare professionals to avoid the use of higher than recommended doses of haloperidol, marketed as Haldol, Haldol Decanoate and Haldol Lactate. In addition to this warning, the FDA also emphasized that the injectable form of haloperidol is only approved to be administered as an intramuscular injection. Common off – label intravenous administration of haloperidol has led to numerous case reports of QT prolongation, Torsades de Piontes (TdP) and sudden death. …

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