Clinical Questions

To Lavage or Not to Lavage?

January 10, 2007
To Lavage or Not to Lavage?

Case and Commentary by Minisha Sood PGY-3 and Ilseung Cho Fellow, Division of Gastroenterology

The patient is a 57 year-old man with a past history of hypetension, hyperlipidemia, hepatitis B/C cirrhosis and coronary artery disease status/post a non-st-elevation mi in August 2006, during which time he was on a heparin drip and developed an upper gastrointestinal bleed. Upper endoscopy at that time revealed non-bleeding esophageal varices and he was discharged on a beta blocker. He again presented to Tisch hospital in December 2006 with complaints…

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Why Are Breast Cancer Rates Trending Down?

January 9, 2007
Why Are Breast Cancer Rates Trending Down?

The recent finding of decreasing breast cancer rates made headlines throughout the media; including a NY Times article entitled, Reversing Trend, Big Drop is seen in Breast Cancer on December 15, 2006.

Striking epidemiological facts tells us that breast cancer is the most common cancer in women in the U.S., and only second to lung cancer as the most common cause of cancer deaths. It is estimated that approximately 212,920 American women will be diagnosed with breast cancer in the year…

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Do Statins Get Along With Hepatitis C?

January 4, 2007
Do Statins Get Along With Hepatitis C?

A 53 year old male with chronic hepatitis C and type 2 diabetes is found to have a moderately elevated cholesterol.

1. Is it safe to start a statin?

2. Do statins have any effect on viral replication?

Comentary By Ed Bini, M.D. Associate Professor/Director Gastroenterology and Hepatology Research

The many benefits of statins far outweigh the risks associated with this class of medications. However, statins are known to have the potential to cause hepatotoxicity. The most common form of statin-induced hepatotoxicity is elevations in…

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Does the Existence of Community Acquired MRSA Change Empiric Therapy for Skin and Soft Tissue Infections?

January 3, 2007
Does the Existence of Community Acquired MRSA Change Empiric Therapy for Skin and Soft Tissue Infections?

A 58 year old man with type 2 diabetes and chronic venous insufficiency/recurrent lower extremity cellulitis presents with fever and a left lower extrmity ulcer with purulent drainage. He’s been successfully treated in the past with both Unasyn/Augmentin or Levaquin.  In the face of community acquired methicillin resistant staph aureus (CA-MRSA),  have guidelines for skin and soft tissue infections changed?

Commentary By Howard Leaf, M.D. Assistant Professor, Division of Infectious Diseases and Immunology

 

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Who Should Receive Prophylaxis for Gout?

December 26, 2006
Who Should Receive Prophylaxis for Gout?

A 70 year old male, former alcoholic, with a past history of gout diagnosed by joint aspiration, presents with his second episode of right 1st metatarsal erythema, swelling and severe pain in the last 6 months.

Commentary By Pamela Rosenthal, MD Assistant Professor of Medicine, Division of Rheumatology

 

Question 1. Is there any specific rule you follow when deciding to start someone on colchicine prophylaxis? e.g. >x # episodes

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Should we recommend mammography screening for women between the ages of 40-50?

December 22, 2006
Should we recommend mammography screening for women between the ages of 40-50?

In a recent article in the Lancet, this question was addressed by a group of investigators led by Sue Moss, Ph.D. from the University of Leeds.  Currently, the  National Cancer Institute, U.S. Preventative Health Services Task Force and the American Cancer Society all recommend screening at a younger age(those between 40-50).  The task force, however, does recommend educating your patients about the potential risks/benefits regarding mammography at a younger age.  Screening women older than 50 has been shown to reduce mortality from breast cancer by…

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How do you approach a patient with Pneumomediastinum?

December 19, 2006
How do you approach a patient with Pneumomediastinum?

BH Morning Report Fast Facts

29 year old male presents with anuria, vomiting, and pneumomediastinum.  1 month prior to admission the patient traveled to South America and developed an upper respiratory infection.  He returned to the US after traveling for two weeks feeling well.   The patient used ecstasy and marijuana four days prior to presentation.  The next day he developed vomiting including one episode of hemetemesis.  For the next three days he had intermittent vomiting, no diarrhea.  On admission his BUN/CR was 68/7.5. …

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Does Circumcision Decrease the Transmission of HIV?

December 18, 2006
Does  Circumcision Decrease the Transmission of HIV?

Recently, two large clinical trials in Kenya and Uganda that examined the role of circumcision in men to prevent the spread of HIV were halted on the grounds that not offering circumcision to men taking part in the trial would be unethical.  The trials involved nearly 3,000 heterosexual men in Kenya and nearly 5,000 men in Uganda, none of whom were infected with HIV prior to starting the trial.  In the Kenayn trial, men who were circumcised had a 53% relative risk reduction (2%…

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When Can You Safely Anticoagulate a Patient after an Intracranial Hemorrhage?

December 15, 2006
When Can You Safely Anticoagulate a Patient after an Intracranial Hemorrhage?

55 year old white male falls down a flight of stairs and sustains a subdural hemorrhage and a subarachnoid hemorhage with significant neurological changes. Hospital course was notable for 1 episode of chest pain without ekg changes and negative cardiac enzymes.  The patient was seen several months later in medicine clinic with resolution of his neurologic findings but now with multiple episodes of chest pain.  He was sent for a stress test which showed a mild reversible anterior wall defect, with normal left ventricle and…

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Epogen and Anemia-Less is More (Part 2)

December 14, 2006
Epogen and Anemia-Less is More (Part 2)

Commentary By David Goldfarb, M.D. Professor of Medicine, NYU Medical Center, Chief Nephrology Section VA New York Harbor

 

2 weeks ago we reported on 2 lead articles in the New England journal that suggested that our targets for hemoglobin values when treating with erythropoietin were too high.

Last week, the New York Times reported that based on those NEJM articles (CHOIR and CREATE), the National Kidney Foundation, which publishes…

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What Is Sezary Syndrome?

December 11, 2006
What Is Sezary Syndrome?

Morning Report-Tisch Hospital

Case Presentation: 83 year old with a past medical history of hypertension noted erytematous plaques with scale about 1 year ago.  The rash was associated with diffuse pruritis at that time.  The patient subsequently underwent several inconclusive biopsies.  She was eventially diagnosed with mycosis fungoides and treated with UV therapy.  Her rash progressed to a diffuse pruritic erythema covering the vast majority of her body, including palms and soles.  (erythroderma).  She was noted to have Sezary cells on peripheral smear and diagnosed…

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How do you approach a patient with asymptomatic primary hyperparathyroidism?

December 6, 2006
How do you approach a patient with asymptomatic primary hyperparathyroidism?

56 year old  Hispanic female with a history of hypertension, type 2 diabetes on oral medications, hyperlipidemia  and normal renal function. Over the past 2 years she has been noted to have mild hypercalcemia (11.0-11.5) on several basic metabolic panels. On her last visit, intact PTH was checked and was elevated at 66 (normal range 7-57). In patients such as this, with apparent asymptomatic primary hyperparathyroidism, what further diagnostic tests should be done and in whom is surgery indicated?…

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