Grand Rounds

Grand Rounds: “Activated Protein C, Translational Research models of Sepsis and Stroke”

January 28, 2009
Grand Rounds: “Activated Protein C, Translational Research models of Sepsis and Stroke”

Commentary by Adi Diab MD, PGY-3

This past week on January 21th, Medical Grand Rounds was given by guest speaker Dr. John Griffin who shared his knowledge of the role of Activate Protein C in both human and murine models of sepsis and stroke.

Activated protein C (APC) is a FDA approved drug that reduces mortality in adult severe sepsis patients, but also increases the risk of serious bleeding. APC exerts anticoagulant activity by proteolysis of factors Va/VIIIa. However, additional clinical trails using…

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Grand Rounds: “VEGF and Renal Thrombotic Microangiopathy”

January 21, 2009
Grand Rounds: “VEGF and Renal Thrombotic Microangiopathy”

Commentary by Ilana Bragin, MD, PGY-3

Please also see the clinical vignette presented before last week’s grand rounds.

Last week’s Medical Grand Rounds was given by guest speaker Dr. Sue Quaggin, Associate Professor of Medicine at the University of Toronto, who shared with the audience her knowledge and passion of the role of Vascular Endothelial Growth Factor (VEGF) in kidney function.  VEGF is a critical family of signaling proteins that is involved in vasculogenesis and angiogenesis. While the discovery of VEGF could be applied to…

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Grand Rounds: “The Cardiovascular Molecular Basis of CPVT and other arrythmias”

January 7, 2009
Grand Rounds: “The Cardiovascular Molecular Basis of CPVT and other arrythmias”

Commentary by Anjali Grover MD, PGY-2 

Please also see the clinical vignette presented before December 17th’s grand rounds.

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is classified as an inherited disorder which manifests itself as an adrenergically driven polymorphic ventricular tachyarrythmias.  The molecular etiology of this arrythmogenic disorder stems from a disruption in the calcium channels found in the sarcoplasmic reticulum.   This type of arrhythmia is an important cause of syncope and sudden cardiac death in those individuals with structurally normal hearts.  Genetic studies…

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Grand Rounds: “Evidence-Based Physical Exam”

December 10, 2008
Grand Rounds: “Evidence-Based Physical Exam”

Commentary by Steven Giovannone MD, PGY-2

Please also see the clinical vignette presented before last week’s grand rounds.

This week’s Medical Grand Rounds was given by Dr. Steven McGee from the University of Washington School of Medicine, author of the well-known textbook “Evidence-Based Physical Diagnosis”.  His lecture, entitled “Evidence-Based Physical Exam,” targeted the utility of the physical exam in an era of increasingly used alternative diagnostic modalities, especially imaging procedures.

In his talk, Dr. McGee first noted that for several medical conditions, physical diagnosis is still the gold…

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Grand Rounds: “Combating the Poverty Associated Tropical Diseases”

December 3, 2008
Grand Rounds: “Combating the Poverty Associated Tropical Diseases”

 

Commentary by Alpana Marwaha MD PGY-3

Please also see the clinical vignette presented before last week’s grand rounds.

This week, the Department of Medicine Grand Rounds was presented by Dr. Peter Hotez MD, PhD and chair of the Department of Microbiology and Tropical Medicine at GW Medical Center. The talk was entitled, “Combating The Poverty Associated Tropical Diseases.”

 

There are a staggering 1.4 Billion people living at wages below $ 1.25 per day known as the “The Bottom Billion.”…

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Grand Rounds: “Advances in the Therapy of HER2 Positive Breast Cancer

November 19, 2008
Grand Rounds: “Advances in the Therapy of HER2 Positive Breast Cancer

Commentary by Jon-Emile Kenny MD, PGY- 2

 

Please also see the clinical vignette presented before last week’s grand rounds.

Medical grand rounds on November 12, 2008 was given by Dr. Jose Baselga, MD.  His lecture, ‘Advances in the Therapy of HER2 Positive Breast Cancer’ highlighted the biochemical aspects of HER receptors and the current and future pharmacological implications thereof.

Roughly one in four breast cancers are HER2 receptor positive.  Phenotypically, these cancers tend to present as locally advanced tumours at an…

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Grand Rounds: “A New Mechanism of Platelet Thrombus Regulation Induced by ADAMTS-18: Clinical Implications”

November 6, 2008
Grand Rounds: “A New Mechanism of Platelet Thrombus Regulation Induced by ADAMTS-18: Clinical Implications”

Commentary by Yelena Kopyltsova MD, PGY-2

Please also see the clinical vignette presented before last week’s grand rounds.

Last week’s grand rounds speaker was Simon Karpatkin MD, NYU Professor of Medicine & Director of the NYU Division of Hematology. In the 80s, multiple cases of autoimmune thrombocytopenic purpura were observed in patients with AIDS.  It was noted that these patients had elevated anti-platelet IgG levels (extracted from immune complexes), which correlated strongly with low platelets.  Dr. Karpatkin and his colleagues became interested in elucidating the mechanism…

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Grand Rounds: State of the Science: Current/Future Directions and Controversies in Health Literacy Research

October 29, 2008
Grand Rounds: State of the Science: Current/Future Directions and Controversies in Health Literacy Research

Commentary by Rosemary Adamson MD, PGY-3

Please also see the clinical vignette presented before last week’s grand rounds. 

The topic of medicine grand rounds this week, health literacy, seemed likely to be dear to the heart of any Bellevue doctor, but I was astounded to learn that the average reading level in the US is that of a 7th or 8th grader, making this topic much more widely applicable than I had thought. Research has demonstrated that low literacy…

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Grand Rounds: “Novel Applications of Erythropoietin in Cardiovascular Disease”

October 22, 2008
Grand Rounds: “Novel Applications of Erythropoietin in Cardiovascular Disease”

Commentary by Srikant Duggirala MD, PGY-2

Please also see the clinical vignette presented during this week’s grand rounds

 

On Wednesday, October, 15, 2008, the NYU Department of Medicine Grand Rounds featured one of its own guest speakers, Stuart Katz M.D., Professor of Medicine and Director of Heart Failure at NYU School of Medicine, with his lecture entitled “Novel Applications of Erythropoietin in Cardiovascular Disease.”

Dr. Katz began his lecture with a discussion of oxygen uptake in a various individuals such as elite…

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Grand Rounds: “Molecular Genetics of Colorectal Cancer”

October 19, 2008
Grand Rounds: “Molecular Genetics of Colorectal Cancer”

Commentary by Sabina Berezovskaya MD PGY-3

Please also see the clinical vignette presented during last week’s grand rounds

On Wednesday, October 8, 2004, the NYU Department of Medicine Grand Rounds featured guest lecturer Vincent Yang, M.D. Ph.D., Professor of Medicine and Director of  Division of Digestive Diseases at Emory University School Medicine with a presentation entitled  “Molecular Genetics of Colorectal Cancer”.

 

Dr. Yang first oriented the audience to the outline of the talk and began his presentation with a case…

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Grand Rounds: “Behcet’s Disease: What It Is, and Isn’t”

October 16, 2008
Grand Rounds: “Behcet’s Disease: What It Is, and Isn’t”

Commentary by Jon-Emile Kenny MD, PGY- 2

Please also see the clinical vignette presented during last week’s grand rounds

Dr.  Yusuf Yazici of the NYU Behcet’s Syndrome Center opened his talk by discussing the classic triad of symptoms characteristic of Behcet’s Disease: aphthous ulcers, genital ulcers and uveitis.  This was originally characterized by the Turkish physician Hulusi Behcet in 1937.  While these symptoms are the most common of Behcet’s, other tissues may be affected as Behcet’s is a systemic vasculitic disorder.  GI symptoms, neurological sequelae, the pathergy…

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Grand Rounds: Clinical Development of Anti-Cancer Drugs: Succeed Slowly or Fail Fast

October 3, 2008
Grand Rounds: Clinical Development of Anti-Cancer Drugs: Succeed Slowly or Fail Fast

Commentary by Daniel Egan MD, PGY2

Please also see the clinical vignette presented during last week’sgrand rounds

On Wednesday, September 24, 2008, the NYU Department of Medicine Grand Rounds featured guest speaker Hilary Calvert, MD, Professor of Medical Oncology at the University of Newcastle upon Tyne, England, with a lecture entitled “Clinical Development of Anti-Cancer Drugs: Succeed Slowly or Fail Fast.”

Dr. Calvert first oriented the audience by reviewing the traditional method in which new chemotherapeutic drugs have been developed and introduced to the…

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