Grand Rounds

Grand Rounds: Regulation of Mammalian Iron Metabolism Reveals a Link to Inflammation

March 25, 2009
Grand Rounds: Regulation of Mammalian Iron Metabolism Reveals a Link to Inflammation

Commentary by Beth Haskins, MD, PGY-3 

Please also see the clinical vignette presented before grand rounds on the 25th of February.

In eukaryotes, iron is a required element but can be toxic at high levels, and thus is tightly regulated. Iron is regulated mainly through acquisitions since there is no excretory route for iron. Entry of iron into plasma occurs through dietary consumption of iron and, to a larger extent, through the recycling of iron from erythrocytes.

The dietary intake of iron of the average …

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Grand Rounds: The New Frontier of Sleep Disorders

March 18, 2009
Grand Rounds: The New Frontier of Sleep Disorders

Commentary by Melissa Price, MD, PGY-3

Please also see the clinical vignette presented before last week’s Grand Rounds.

At Medical Grand Rounds on March 11th, 2009, the NYU Medical Community had the immense pleasure of hosting Dr. Allan I. Pack, MD, Ch.B, and Ph.D from the University of Pennsylvania Medical Center as he indulged us in his research on the biological functions of sleep and its regulation.

Studying the importance of sleep and its disorders has never been more relevant. Not only is the Accreditation …

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Grand Rounds: Gout and Hyperuricemia: Some New Thoughts About an Old Disease

March 11, 2009
Grand Rounds: Gout and Hyperuricemia: Some New Thoughts About an Old Disease

Commentary by Deena Altman MD, PGY-2

Please also see the clinical vignette presented before grand rounds on February 18th.

At medical grand rounds on February 18, 2009, our very own Dr. Pillinger gave a unique overview of the history, pathogenesis, and new theories on an ancient and increasingly common disease, gout.

His talk began with a depiction of gout throughout the ages. Podagra was first described in 2600 BC, with the first urate crystals being recognized in 1961 by polarizing microscope. While noting that Charles …

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Grand Rounds: “Health Care Access and Its Impact on Health Disparities”

February 11, 2009
Grand Rounds: “Health Care Access and Its Impact on Health Disparities”

Commentary by Zackary Berger MD PhD, PGY-3, Health Care Policy Section Editor 

As Massachusetts’ Secretary of Health and Human Services, JudyAnn Bigby, MD, is charged with overseeing the health-care program which covers nearly all of the Commonwealth’s residents (nearly 98%) while costing more than anyone expected (about 800 million dollars in 2008). On February 4th, Dr. Bigby spoke at NYU’s Medicine Grand Rounds, where she summarized the approach and accomplishments of Title 58, the health care legislation passed in 2006. The program had several goals: …

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Grand Rounds: “Activated Protein C, Translational Research models of Sepsis and Stroke”

January 28, 2009
Grand Rounds: “Activated Protein C, Translational Research models of Sepsis and Stroke”

Commentary by Adi Diab MD, PGY-3

This past week on January 21th, Medical Grand Rounds was given by guest speaker Dr. John Griffin who shared his knowledge of the role of Activate Protein C in both human and murine models of sepsis and stroke.

Activated protein C (APC) is a FDA approved drug that reduces mortality in adult severe sepsis patients, but also increases the risk of serious bleeding. APC exerts anticoagulant activity by proteolysis of factors Va/VIIIa. However, additional clinical trails using other anticoagulants, …

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Grand Rounds: “VEGF and Renal Thrombotic Microangiopathy”

January 21, 2009
Grand Rounds: “VEGF and Renal Thrombotic Microangiopathy”

Commentary by Ilana Bragin, MD, PGY-3

Please also see the clinical vignette presented before last week’s grand rounds.

Last week’s Medical Grand Rounds was given by guest speaker Dr. Sue Quaggin, Associate Professor of Medicine at the University of Toronto, who shared with the audience her knowledge and passion of the role of Vascular Endothelial Growth Factor (VEGF) in kidney function.  VEGF is a critical family of signaling proteins that is involved in vasculogenesis and angiogenesis. While the discovery of VEGF could be applied to …

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Grand Rounds: “The Cardiovascular Molecular Basis of CPVT and other arrythmias”

January 7, 2009
Grand Rounds: “The Cardiovascular Molecular Basis of CPVT and other arrythmias”

Commentary by Anjali Grover MD, PGY-2 

Please also see the clinical vignette presented before December 17th’s grand rounds.

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is classified as an inherited disorder which manifests itself as an adrenergically driven polymorphic ventricular tachyarrythmias.  The molecular etiology of this arrythmogenic disorder stems from a disruption in the calcium channels found in the sarcoplasmic reticulum.   This type of arrhythmia is an important cause of syncope and sudden cardiac death in those individuals with structurally normal hearts.  Genetic studies have elucidated two …

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Grand Rounds: “Evidence-Based Physical Exam”

December 10, 2008
Grand Rounds: “Evidence-Based Physical Exam”

Commentary by Steven Giovannone MD, PGY-2

Please also see the clinical vignette presented before last week’s grand rounds.

This week’s Medical Grand Rounds was given by Dr. Steven McGee from the University of Washington School of Medicine, author of the well-known textbook “Evidence-Based Physical Diagnosis”.  His lecture, entitled “Evidence-Based Physical Exam,” targeted the utility of the physical exam in an era of increasingly used alternative diagnostic modalities, especially imaging procedures.

In his talk, Dr. McGee first noted that for several medical conditions, physical diagnosis is …

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