Grand Rounds

Grand Rounds: “Innate Immunity and Viral Pathogenesis”

December 4, 2007

Commentary by Urania Rappo, PGY-2

This week’s Medicine Grand Rounds guest lecturer was Dr. Robert Finberg, currently Chair of the Department of Medicine at the University of Massachusetts Medical School. He earned his MD from Albert Einstein College of Medicine and trained in Medicine at Bellevue Hospital starting in 1974. He was a Fellow in Infectious Diseases at Harvard Medical School, and there established a rich research career over the ensuing twenty years. Dr. Finberg’s research focuses on host-microbial interactions, defining the cell surface proteins…

Grand Rounds: Breast Cancer Genomics

November 20, 2007

Commentary by Jonathan Willner MD, PGY-2

This week’s Medicine Grand Rounds speaker was Lisa Carey, MD, Associate Professor in Hematology/Oncology at the University of North Carolina and Medical Director of the UNC Breast Center. Much of Dr. Carey’s research focuses on how an understanding of breast cancer genomics may tailor clinical therapy.

While the incidence of breast cancer has plateaued over the past few years, there has been a decline in the number of breast cancer deaths. The reason is thought to…

Grand Rounds: “Pseudomonas aeruginosa Pathogenesis-Studies of an Opportunist”

November 9, 2007

Welcome to our Grand Rounds Series. Each week, we plan to post a summary of the week’s Medicine Grand Rounds lecture. The summaries are reviewed and approved by the grand rounds speaker prior to posting.

Commentary by Ryan Farley MD, PGY-3

This week’s Medicine Grand Rounds guest lecturer was Dr. Barbara Kazmierczak , currently Associate Professor of Medicine and Microbial Pathogenesis at Yale University School of Medicine. Dr. Kazmierczak is the principal investigator for several NIH grants studying Pseudomonas aeruginosa virulence…

Grand Rounds: “Towards Biologically Rational Therapy for Myelodysplastic Sydrome.”

November 2, 2007

Welcome to our new Grand Rounds Series. Each week, we plan to post a summary of the week’s Medicine Grand Rounds lecture. The summaries are reviewed and approved by the grand rounds speaker prior to posting. Enjoy.

Commentary by Marshall Fordyce MD, Senior Chief Resident

This week’s Medicine Grand Rounds guest lecturer was Dr. Steven Gore, currently Associate Professor of Oncology, and Faculty Member of Cell and Molecular Medicine, at the Johns Hopkins University School of Medicine. Dr. Gore’s research focuses on improving…

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Clinical Corner

Are there specific factors that influence the odds of nonadherence to prescribed medication in primary care?

In this cohort study, 15,961 patients were followed along with all of their incident prescriptions from primary care clinic between 2006-2009. Primary nonadherence was defined as not filling an incident prescription within 9 months. Results showed that 37, 506 incident prescriptions were written within that timeframe out of which 31.3% were not filled. More expensive medications were least likely to be filled (OR 1.11, 95% CI 1.07-1.17) as well as dermatological agents, gastrointestinal drugs and autonomic medications compared to antibiotic drugs. Decreased odds of nonadherence was associated with increasing patient age (OR per 10 years, 0.89, CI 0.85-9.92), no co-payments for prescriptions for low-income groups (OR 0.37, CI 0.32-0.41), and having most of the clinic visits with the prescribing physician (OR per 0.5 increase, 0.77, CI 0.70-0.85). Thus, nonadherence may be reduced by prescribing more inexpensive medications, eliminating co-payments for low-income patients, and scheduling more follow-up care with the prescribing physician.

Tamblyn et al. Ann Intern Med 2014;160(7):441-50

Clinical Correlations

Grand Rounds

Grand Rounds: “Innate Immunity and Viral Pathogenesis”

Grand Rounds: Breast Cancer Genomics

Grand Rounds: “Pseudomonas aeruginosa Pathogenesis-Studies of an Opportunist”

Grand Rounds: “Towards Biologically Rational Therapy for Myelodysplastic Sydrome.”

Clinical Corner

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