Evans Syndrome, first described by Evans and Duane in 1949, refers to the combination of Coombs-positive warm autoimmune hemolytic anemia and immune thrombocytopenia (ITP). The syndrome can be primary or associated with systemic lupus, immune disorders, lymphoproliferative disorders or immunodeficiencies. The antibodies that cause hemolysis are different from those that cause platelet destruction. Those causing hemolysis are directed against a base protein portion of the Rh blood group, while those that destroy platelets are frequently directed against platelet GPIIb/IIIa.
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