Alzheimer’s Disease 2.0

April 21, 2010
Alzheimer’s Disease 2.0

Jeffery Mayne MD

Faculty peer reviewed

Dr. Okonkwo’s post this past summer to PrimeCuts summarized ongoing research in Alzheimer’s Disease (AD), the most common cause of dementia affecting 15 million individuals worldwide and more than 5 million in the United States. It is a disease marked by cognitive deterioration that slowly breaks down one’s ability to perform activities of daily living and leaves individuals unable to care for themselves.

Briefly, the diagnosis of AD is based on clinical criteria and histologic confirmation at death. Based …

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Primecuts: This Week in the Journals

April 19, 2010
Primecuts: This Week in the Journals

Chau Che, MD

Faculty Peer Reviewed

In the economic news this week, the Dow Jones Industrial Average closed above 11,000 for the first time since September 2008.  It appears that the economy is rebounding, and despite the news of fraud charges against Goldman Sachs at the end of the week, the Dow Jones still managed to close the week above 11,000.  This provides hope that the United States is heading towards economic recovery. The medical journals also echoed hopes of recovery by addressing recovery from …

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Which Thyroid Antibody Assays Should be Checked in Patients with Thyroid Disease?

April 14, 2010
Which Thyroid Antibody Assays Should be Checked in Patients with Thyroid Disease?

Michael Chu MD

Faculty peer reviewed

Case:

A 44-year old female presented to the emergency room with complaints of a lower extremity rash and swelling.  The patient had been in her usual state of health when she presented to her primary care physician with complaints of palpitations, weight loss and insomnia.  Lab tests were performed and she was given a diagnosis of hyperthyroidism.  She was started on propranolol and methimazole, which the patient took intermittently due to intolerance of side effects, which she perceived as …

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Primecuts: This Week in the Journals

April 12, 2010
Primecuts: This Week in the Journals

Robert Gianotti, MD

Faculty Peer Reviewed

Welcome back to this week’s edition of prime cuts. For all you sports fans out there it has been filled with some exciting comebacks and breaking news. Earlier in the week, Duke was restored as the number one team in the nation as they edged out the Butler Bulldogs (61-59) to return to their former glory as the best in the NCAA. This week also marks the 74th Masters Golf Tournament featuring none other than Tiger Woods making his …

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Antimicrobial Therapy Geared at Pseudomonas aeruginosa for Bronchiectasis

April 7, 2010
Antimicrobial Therapy Geared at Pseudomonas aeruginosa for Bronchiectasis

Diana Hubulashvili, Pharm.D.

Edited by Tania Ahuja, Pharm.D., BCPS

Faculty peer reviewed

Bronchiectasis is an uncommon condition that is characterized by irreversible dilation of the bronchi. Chronic pulmonary infections and airway inflammation cause bronchial damage through destruction of the muscular and elastic layer of the bronchial wall leading to bronchiectasis. Bronchiectasis is associated with serious pulmonary infections, inflammation, chronic cough, and increased sputum production...

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PrimeCuts: This Week in the Journals

April 5, 2010
PrimeCuts: This Week in the Journals

Ankit Parikh MD

Faculty peer reviewed

It is time for the first Primecuts of April and the signs of spring are all around us. But before we spring forward into this edition of Primecuts, let us take a look back and reflect on “March Madness.” With all apologies to fans of Butler and Duke, this year “March Madness” was all about the historic battle for health care reform and passage of the Patient Protection and Affordable Care Act two weeks ago. In the face of …

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Breaking News: The Crestor Controversy

April 1, 2010
Breaking News: The Crestor Controversy

Devyani Kothari, MD

Patients are already talking about a New York Times front page article highlighting the risks associated with statin use as a preventive measure for cardiovascular events in relatively “healthy” people. The piece examines the newest FDA indications for the use of Crestor along with the controversies surrounding the drug.

Last month, the FDA approved Rosuvastatin Calcium, marketed as Crestor by AstraZeneca for use in a new patient population , based on the JUPITER trial. Crestor now carries the indication for the primary …

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How Easily is Tuberculosis Spread?

March 31, 2010
How Easily is Tuberculosis Spread?

Molly Cason

Faculty peer reviewed

In a city of over 8 million people, New York City has an annual tuberculosis case rate of 11.4 per 100,000 people, which is more than twice the national average.  Seventy-one percent of these cases occur in people who were born outside the United States.1 As a student, I had a patient (Y) who was being evaluated for active tuberculosis because he is a household contact of a person (X) known to have active multi-drug resistant tuberculosis. I wondered what …

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