Happy Thanksgiving

November 21, 2007
Happy Thanksgiving

Clinical Correlations will be closed for the holiday and will resume posting on Monday 11/26/07.  Have a very happy Thanksgiving and remember, be careful with that turkey…

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Clinical Pathology Conference 11/9/07- The Answer

November 21, 2007

Case Presentation by Shrujal Baxi MD, Chief Resident

Please review the posting of last week’s CPC here.

When you’re ready you can download the CPC Answer.

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Grand Rounds: Breast Cancer Genomics

November 20, 2007
Grand Rounds: Breast Cancer Genomics

Commentary by Jonathan Willner MD, PGY-2

This week’s Medicine Grand Rounds speaker was Lisa Carey, MD, Associate Professor in Hematology/Oncology at the University of North Carolina and Medical Director of the UNC Breast Center.  Much of Dr. Carey’s research focuses on how an understanding of breast cancer genomics may tailor clinical therapy.

While the incidence of breast cancer has plateaued over the past few years, there has been a decline in the number of breast cancer deaths. The reason is thought to…

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ShortCuts-This Week in the Journals

November 19, 2007
ShortCuts-This Week in the Journals

Commentary by Cara Litvin MD, Executive Editor, Clinical Correlations

As winter quickly approaches and we plunge into flu season, it’s fitting that news of a “killer” cold virus broke last week. According to a CDC report, adenovirus serotype 14 (Ad14) is an emerging strain of adenovirus that may cause severe respiratory illness and even death in people of all ages, including healthy young adults. The virus has been linked to 140 cases in 4 states (including NY) between 2006 and 2007. Over a…

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Treatment of obesity with bariatric surgery: evidence and implications

November 15, 2007
Treatment of obesity with bariatric surgery: evidence and implications

Commentary by Jatin Roper MD PGY-3 and Christine Ren MD Associate Professor, Department of Surgery

Bariatric procedures to treat obesity involve the restriction of the gastric reservoir, bypass of part of the gastrointestinal tract, or both. Worldwide, an estimated 300 million people are obese, and in the United States, the percentage of adults who are obese increased from 15% in 1995 to 24% in 2005. (Obesity is defined as a Body Mass Index or BMI of 30 or more, measured as kg /…

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FDA Approves Raltegravir- A First in New Class of HIV Medications

November 14, 2007
FDA Approves Raltegravir- A First in New Class of HIV Medications

Commentary by Helen Kourlas PharmD, Pharmacology Section Editor

On October 16th the FDA announced the approval of raltegravir (Isentress®) for the treatment of Human Immunodeficiency Virus (HIV)-1 infection in combination with other antiretroviral agents. The use of raltegravir is recommended for patients who have HIV-1 strains resistant to multiple antiretroviral medications. Raltegravir belongs to a new pharmacologic class of antiretrovirals called HIV integrase strand transfer inhibitors. Integrase is one of the three enzymes necessary for the HIV-1 virus to replicate, and integrase inhibitors can stop the…

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ShortCuts-This Week in the Journals

November 13, 2007
ShortCuts-This Week in the Journals

Commentary by Judith Brenner MD, Associate Program Director, NYU Internal Medicine Residency Program

Published early online in NEJM comes the CORONA study “Rosuvastatin in Older Patients with Systolic Heart Failure”. In this trial, 5000 patients with class II, III and IV ischemic, systolic heart failure were randomized to receive placebo or rosuvastatin 10 mg. In prior statin trials, patients with reduced ejection fractions were not included, so this trial is important for that reason. The results surprisingly revealed no significant differences between the…

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Grand Rounds: “Pseudomonas aeruginosa Pathogenesis-Studies of an Opportunist”

November 9, 2007
Grand Rounds: “Pseudomonas aeruginosa Pathogenesis-Studies of an Opportunist”

Welcome to our Grand Rounds Series. Each week, we plan to post a summary of the week’s Medicine Grand Rounds lecture. The summaries are reviewed and approved by the grand rounds speaker prior to posting.

Commentary by Ryan Farley MD, PGY-3

This week’s Medicine Grand Rounds guest lecturer was Dr. Barbara Kazmierczak , currently Associate Professor of Medicine and Microbial Pathogenesis at Yale University School of Medicine.  Dr. Kazmierczak is the principal investigator for several NIH grants studying Pseudomonas aeruginosa virulence…

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