Shortcuts-This Week in the Journals

January 22, 2008
Shortcuts-This Week in the Journals

Commentary by Sean Cavanaugh MD, Associate Editor, Clinical Correlations

If you think the modern scientific literature is reading more and more like science fiction each day, get a load of this: apparently they are growing hearts in Minneapolis. More than an interestingly macabre headline, this represents a significant advancement toward a dream long held by transplant physicians, and allows for a more vivid imagining of the day when we have the technology to grow organs from an individual’s own stem cells. The accomplishment,…

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Health Care 2008: Where the Candidates Stand- Part 3 Edwards, McCain and Romney

January 18, 2008
Health Care 2008: Where the Candidates Stand- Part 3 Edwards, McCain and Romney

In this series, we are trying to cut through some of the media hype in order to summarize the health care proposals put forward by the leading candidates for President.

Commentary by Aaron Lord MD, PGY-1

Our third post presents the plans of one Democrat and two Republicans.

John Edwards (D)

The “Edwards Plan for Universal Health Care” would create a system of regional, non-profit “Health Care Markets” — collectives of discount insurance plans. Individuals could choose from any one…

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Grand Rounds: “Two patients with splenomegaly: what is the diagnosis?”

January 17, 2008
Grand Rounds: “Two patients with splenomegaly: what is the diagnosis?”

Commentary by Noga Chlamtac MD, PGY 3

This weeks grand rounds was delivered by Dr. Pramod Mistry, Professor of Pediatrics and Medicine, and Chief of the Section of Pediatric Gastroenterology, Hepatology and Nutrition at Yale School of Medicine. Dr. Mistry received his Ph.D degree from the St. Thomas Hospital Medical School at the University of London in 1979 and his clinical training at the Royal Free Hospital and the Royal College of Physicians. Starting in 1998, he served as the Director of the Comprehensive…

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Breaking News: A Disappointment for Zetia

January 15, 2008
Breaking News: A Disappointment for Zetia

Commentary by Alana Choy-Shan MD, NYU Chief Resident

The highly anticipated results of the ENHANCE trial will likely be presented at the American College of Cardiology meeting in March, but the preliminary results already have everyone talking. ENHANCE was a multinational, double-blind randomized controlled trial sponsored by Merck and Schering-Plough (the manufacturers of the combination ezetimibe/simvastatin pill). A total of 720 patients who were heterozygotes for Familial Hypercholesterolemia were randomized to treatment with either ezetimibe/simvastatin 10/80mg or simvastatin 80mg. The primary endpoint was change in…

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ShortCuts-This Week in the Journals

January 14, 2008
ShortCuts-This Week in the Journals

Commentary by Cara Litvin MD, Executive Editor, Clinical Correlations

Published in the NEJM this week was a study intended to conclusively determine whether corticosteroids are an effective adjunctive therapy in severe sepsis. Although corticosteroid use is a widely accepted therapy for the treatment of sepsis, prior evidence supporting this practice has been lacking. In this multicenter randomized double-blind trial (CORTICUS), ICU patients were randomized to receive a full course of hydrocortisone therapy versus placebo. Corticotropin stimulation tests were performed in all patients. The…

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Class Act: Do Statins Always Have to Be Taken in the Evening?

January 10, 2008
Class Act: Do Statins Always Have to Be Taken in the Evening?

Class act is a feature of Clinical Correlations written by NYU 3rd and 4th year medical students. These posts focus on evidenced based answers to clinical questions related to patients seen by our students in the clinics or on the wards. Prior to publication, each commentary is thoroughly reviewed for content by a faculty member. Enjoy…

Commentary by David Leaf, MSIV

HMG-CoA reductase inhibitors (statins) are the most powerful drugs used for lowering LDL cholesterol, with median reductions in the range of 30 to 63…

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Health Care 2008: Where Do the Candidates Stand? Part 2-Obama and Thompson

January 8, 2008
Health Care 2008: Where Do the Candidates Stand? Part 2-Obama and Thompson

In this series, we try to cut through some of the media hype and summarize the health care proposals put forward by the leading candidates for President.

Commentary by Aaron Lord MD, PGY-1

With the New Hampshire primaries upon us, there’s no time to lose! Here’s a summary of the health plans of two more candidates, Senators Barack Obama and Fred Thompson.

Barack Obama (D)

Like Hillary Clinton’s plan (see the first post in this series), as well as…

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ShortCuts-This Week in the Journals

January 7, 2008
ShortCuts-This Week in the Journals

Commentary by Judith Brenner MD, Associate Program Director, NYU Internal Medicine Residency Program

This week’s Annals of Internal Medicine focused on angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB). Two studies addressed questions such as: Which class (ACE/ARB or both) is more effective as an anti-hypertensive? Which class is more effective for proteinuria? What are the adverse events of the combination? What are long term outcomes?

The first article was a systematic review that compares these drugs as anti-hypertensive agents.…

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