Happy Thanksgiving

November 28, 2013
Happy Thanksgiving

Clinical Correlations will be closed for the holiday and will resume posting on Monday 12/2/13.  Have a wonderful Thanksgiving and remember, please be careful with that turkey…

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Primecuts – This Week In The Journals

November 25, 2013
Primecuts – This Week In The Journals

By Ali Mendelson, MD

Faculty Peer Reviewed

With Thanksgiving quickly approaching, the holidays are on everybody’s mind. There are parades to watch, food to cook, thanks to give, and inevitably, diets to break. That doesn’t mean you can’t find time to exercise, and for those who are pregnant, fitting in a few trips to the gym might aid in the development of your unborn child’s brain.

Two studies presented at this month’s Society for Neuroscience’s annual meeting looked at the association between exercise and infant…

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To Stent or not to Stent? A Review of the Evidence on the Utility of Stenting in Renal Artery Stenosis

November 22, 2013
To Stent or not to Stent? A Review of the Evidence on the Utility of Stenting in Renal Artery Stenosis

By Elizabeth Hammer, MD

Faculty Peer Reviewed

Renovascular hypertension, often caused by renal artery stenosis (RAS) due to atherosclerosis or fibromuscular dysplasia, is the most common potentially correctable cause of secondary hypertension. Although only approximately one percent of patients with hypertension have atherosclerotic renovascular disease (ARVD), the prevalence increases to 30-40% in patients with CAD, CHF, and PVD. Screening studies of asymptomatic populations in the United States demonstrate a disease prevalence of 7%, with an annual incidence of 0.5% per year in analyses of…

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From The Archives: The Polymyxins: Why am I using them all the time, and what are they?

November 21, 2013
From The Archives: The Polymyxins: Why am I using them all the time, and what are they?

Please enjoy this post from the archives dated December 8, 2010

By Jon-Emile S Kenny

Faculty Peer Reviewed

A 65-year-old female with locally advanced rectal cancer is admitted to the ICU, hypotensive and febrile. Her PICC line is removed and blood cultures drawn. Fourty-eight hours later all cultures return ESBL Klebsiella with susceptibility only to polymyxin.

I sat on the venerable call-room couch staring mindlessly at the cluttered, nauseating walls repeating the word ‘polymyxin’ like an endless antimicrobial mantra. What strange dosing it has, and…

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Fever: Friend or Foe?

November 20, 2013
Fever: Friend or Foe?

By Fernando Franco Cuadrado, MD, Julia Hyland Bruno, MD and  Mark D. Schwartz, MD

Faculty Peer Reviewed

When flu season returns, we will all see patients with sniffles, aches and a mild to moderate fever. History, tradition and habit have made the treatment of fevers almost automatic; however, how many of us pause and consider evolutionary principles before recommending acetaminophen for a fever? Could fever have an adaptive function? Are we sure we are doing more good than harm by recommending antipyretics?

To most…

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Primecuts – This Week In The Journals

November 18, 2013
Primecuts – This Week In The Journals

By Karin Katz, MD

Faculty Peer Reviewed

Last week Typhoon Haiyan took a devastating hit on the Philippines. According to UNICEF, 13 million people have been affected, and the death toll is estimated to be close to 4,000. In the aftermath of this disaster, with hundreds of thousands of people homeless, there is a concern that crowded living spaces with contaminated drinking water and unsanitary conditions could lead to the spread of communicable diseases. International relief efforts have been working to provide people with food,…

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BREAKING NEWS: New ACC/AHA Guidelines on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults

November 13, 2013
BREAKING NEWS: New ACC/AHA Guidelines on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults

By Sherif Shoucri, MD

Yesterday, the American College of Cardiology and American Heart Association released new groundbreaking guidelines on the treatment of blood cholesterol. These recommendations, which officially drop LDL target levels for patients on statin therapy, will fundamentally alter the way most primary care physicians and cardiologists treat hyperlipidemia. After reviewing the available data on statins, the authors concluded that there was no evidence to support an LDL target of either 70 or 100. Rather, patients should be placed on either moderate-intensity (lowers…

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Primecuts – This Week In The Journals

November 12, 2013
Primecuts – This Week In The Journals

By Sherif Shoucri, MD

Faculty Peer Reviewed

In a move that was almost thirty years in the making, this week the Food and Drug Administration proposed measures that would all-but outlaw artificial trans fats. These artery-clogging, partially hydrogenated oils have long been implicated as a major contributor to heart disease in the United States. Their removal from the U.S. food industry could prevent as many as 20,000 heart attacks and 7,000 deaths from heart disease each year, according to data cited by the FDA. While…

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