Case Presentation by Alana Choy-Shan MD, Chief Resident
Please review the posting of our prior CPC here.
When you’re ready you can download the CPC Answer.
hERG (human ether-a-go-go-related gene) K+ channels play an important role in phase 3 repolarization (rapid delayed rectifier K+ current) of the ventricular myocyte action potential. Inherited mutations in the HERG gene cause long QT syndrome, while drug-induced QT prolongation and torsade de pointes are caused by direct blockage of the hERG channels. Pharmaceutical companies now screen drugs for hERG channel activity, however not all blockage of the hERG cannel result in QT prolongation, limiting the usefulness of screening.
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