Core IM: Mind the Gap on Prescribing Meds Day vs. Night Part 1

May 12, 2019

For a transcript of the podcast and show notes:

Time Stamps

  • Why do we dose warfarin at night? (2:45)
  • Back to the basics – what are the pharmacodynamics of warfarin and how does vitamin K intake matter? (4:28)
  • Practical matters – so what should we tell patients (6:14)
  • Dippers and non-dippers – what happens to blood pressure at night? (9:32)
  • The surprising link between dipping and cardiovascular outcomes (11:15)
  • Timing is everything… or is it? The evidence behind taking BP meds at night (11:58)
  • Review of teaching points (15:58)

Thank you to Dr. Matthew Sparks, Nephrologist at Duke and Tania Ahuja, pharmacist at NYU Langone Health for peer-reviewing this episode!


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