Primecuts – This Week In The Journals

October 5, 2015
Primecuts – This Week In The Journals

Olivia Begasse de Dhaem, MD

Peer Reviewed  

Last month, Turing Pharmaceutical bought the rights to pyrimethamine, also known as Daraprim, and subsequently raised its price significantly (from $13.5 to $750 per tablet). Unlike Rodelis Therapeutics who gave back cycloserine when facing resistance, Turing Pharmaceuticals are determined to keep their newly increased price for Daraprim. The new trend in the pharmaceutical world of acquiring old medications and increasing their prices has led to controversy on whether the government should take action in regulating pharmaceutical prices and …

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From The Archives: Does the BCG Vaccine Really Work?

October 1, 2015
From The Archives: Does the BCG Vaccine Really Work?

Please enjoy this post from the archives dated March 14, 2012

By Mitchell Kim

Faculty Peer Reviewed

Mycobacterium tuberculosis, an acid-fast bacillus, is the causative agent of tuberculosis (TB), an infection that causes significant morbidity and mortality worldwide. A highly contagious infection, TB is spread by aerosolized pulmonary droplet nuclei containing the infective organism. Most infections manifest as pulmonary disease, but TB is also known to cause meningitis, vertebral osteomyelitis, and other systemic diseases through hematogenous dissemination. In 2009, there were an estimated 9.4 million …

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HDL Quantity, Necessary But Not Sufficient For Cardioprotection

September 30, 2015
HDL Quantity, Necessary But Not Sufficient For Cardioprotection

By Kerrilynn Carney, MD

Peer Reviewed

Coronary heart disease remains the leading cause of death globally despite the use of statin therapy. Although major statin studies suggest an average 31% reduction in relative risk of coronary events, a residual risk of 69% remains to be addressed. (1) The search for a medical therapy to ameliorate residual risk has become the holy grail of cardiologists and pharmaceutical companies alike. While high-density lipoprotein cholesterol levels (HDL) independently predict cardiovascular disease risk, interventions to raise circulating HDL levels …

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Primecuts – This Week In The Journals

September 28, 2015
Primecuts – This Week In The Journals

Viola Davis accepts the award for Outstanding Lead Actress In A Drama Series for her role in ABC’s “How To Get Away With Murder” during the 67th Primetime Emmy Awards in Los Angeles, California September 20, 2015. REUTERS/Lucy Nicholson

By Jacob J. Spinner, MD

Peer Reviewed

Last week Viola Davis made history as the first black woman to win an Emmy for Best Actress in a Drama. In accepting her award, she gave a moving speech on opportunity and bias against women of color . …

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There’s an App for That: Fitness Apps and Behavior Change Theory

September 18, 2015
There’s an App for That: Fitness Apps and Behavior Change Theory

By Alyson Kaplan

Peer Reviewed

According to recent reports by the CDC, more than one-third (78.6 million) of American adults are obese. Approximately 17% (12.7 million) of children and adolescents ages 2-19 also meet criteria for obesity . Obesity-related health conditions, including diabetes, heart disease, certain types of cancer, and stroke are among the leading causes of preventable death. Yet, obesity is not the sole contributor to these diseases. Other health risk behaviors, including smoking, alcohol abuse, and lack of physical activity all interact to …

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Primecuts-This Week in the Journals

September 16, 2015
Primecuts-This Week in the Journals

By: Miguel A. Saldivar

Last week, the National Institutes of Health (NIH), in conjunction with the National Heart, Lung and Blood Institute (NHLBI) announced the premature ending of what is now being dubbed a landmark study: the Systolic Blood Pressure Intervention Trial (SPRINT) . Preliminary results showed that, in adults over the age of 50, a target systolic blood pressure of 120 mm Hg could reduce the risk of cardiovascular events by almost a third and the risk of death by almost a quarter. But …

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Primecuts – This Week In The Journals

September 1, 2015
Primecuts – This Week In The Journals

By Ofole Mgbako, MD

Peer Reviewed 

This past week marked 10 years since Hurricane Katrina and President Obama visited the Lower Ninth Ward in New Orleans. The president described the hurricane as “a natural disaster” that became “a man-made disaster…a failure of government to look out for its own citizens.” While important progress has been made, the region still faces many economic problems – about one-third of the population and 40% of children live below the poverty line – and over 100,000 African Americans who …

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Primecuts – This Week In The Journals

August 24, 2015
Primecuts – This Week In The Journals

By Neha Sathe, MD 

Peer Reviewed 

As new fires ignite at the enormous Tianjin blast site in northern China, concern mounts regarding exposure to 700 tons of toxic chemicals that had been stored there. The initial explosion, a tragedy that claimed 116 lives and destroyed 17,000 homes, released high levels of such chemicals as sodium cyanide, which continues to affect local air and water quality.

While China moves to control this chemical exposure, Africa celebrates one year without a new case of polio on the …

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