How Much Do We Know About HDL Cholesterol?

January 29, 2014
How Much Do We Know About HDL Cholesterol?

By Gregory Katz, MD

Peer Reviewed

As levels of HDL cholesterol increase, rates of heart disease go down. It’s this fact that has given HDL its reputation as the “good cholesterol,” serving a crucial role in reverse cholesterol transport. According to our models, HDL ferries cholesterol away from our arteries – where its buildup leads to heart disease and stroke – and back towards our liver, safely out of harm’s way. The epidemiology backs this up: people with higher levels of HDL tend to…

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Primecuts – This Week In The Journals

January 27, 2014
Primecuts – This Week In The Journals

By Luke O’Donnell, MD

Peer Reviewed

This was a week of confusion both old and new. How did a chance of flurries become a major winter storm? Did Beyoncé sign “Happy Birthday” to first lady Obama? What strain of cholera caused the 1849 Philadelphia Pandemic?

This week’s medical literature may not have cleared up all these pressing questions, but at least it managed to determine the strain of Vibrio cholerae that caused the devastating Philadelphia cholera outbreak of 1849. Vibrio cholerae’s predominate pathogenic strain—serogroup O1—has…

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Book Review – Medicine’s Michelangelo: The Life & Art of Frank H. Netter, MD

January 24, 2014
Book Review – Medicine’s Michelangelo: The Life & Art of Frank H. Netter, MD

By Matthew Vorsanger, MD

The delicate tracery of the superficial nervous system, the sweeping curves of the lobes of the liver, the bones of the skull – color coded in pastel blues, pinks, and greens. For many of us, the imagery of Dr. Frank Netter’s Atlas of Human Anatomy is indelibly etched into our mind’s eye. But what do we know of the man whose gift it was to distill the most complex anatomic structures into vividly comprehensible illustrations? Recently published by his daughter, Francine…

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Can Young Patients Get Diverticular Disease?

January 23, 2014
Can Young Patients Get Diverticular Disease?

By Aaron Smith, MD

Peer Reviewed

Case: A 35 year-old, overweight female presents to the emergency room with five days of left lower quadrant abdominal pain. The pain is 10/10 in severity and accompanied by nausea, bloating, and loss of appetite.

Diverticulosis, the presence of small colonic outpouchings thought to occur secondary to high pressure within the colon, is an extremely common condition in elderly patients. Recent data suggests that up to 50% of people over the age of 60 have colonic diverticula. When…

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Primecuts – This Week In The Journals

January 21, 2014
Primecuts – This Week In The Journals

By Stephanie Gallitano, MD

Peer Reviewed

This week marks the 50-year anniversary since the Surgeon General released a report detailing health consequences of smoking. Since then, the evidence linking smoking with disease in nearly every organ system has been published. The number of premature deaths caused by smoking or exposure to secondhand smoke since 1965 now tops 20 million. This week’s new surgeon general’s report addresses some new diseases linked with smoking; we can now add colorectal and liver cancer, erectile dysfunction, diabetes, tuberculosis, age-related…

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From The Archives – The Hangover: Pathophysiology and Treatment of an Alcohol-Induced Hangover

January 16, 2014
From The Archives – The Hangover: Pathophysiology and Treatment of an Alcohol-Induced Hangover

Please enjoy this post from the archives, dated May 27, 2011

By Anthony Tolisano

Faculty Peer Reviewed

The sunlight forces its way into your eyes, stabbing at your cortex. Suddenly, a wave of nausea and diarrhea grips your stomach, threatening to evacuate its contents. You rush to the bathroom, tripping over the clothes that speckle your apartment. Your heart pounds inside your chest and your hands shake ever so subtly. Your mind is in a fog and the details of last night’s party are…

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Is it Time to Skip the Gym?

January 15, 2014
Is it Time to Skip the Gym?

By Robert Mocharla, MD

Peer Reviewed

No. Sorry. Despite such reasonable excuses as – “I forgot my iPod”, “It’s pouring rain”, or “Game of Thrones is on” — an exhaustive literature search will not reveal a shred of evidence that you or most of your patients should skip daily exercise. However, a subset of your patients should indeed be skipping workouts regularly. The group referred to consists of endurance athletes (e.g. cyclists, swimmers, long-distance runners, competitive athletes). While this may not describe the majority of…

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Primecuts – This Week In The Journals

January 13, 2014
Primecuts – This Week In The Journals

By Arnab Ghosh, MD

Peer Reviewed

This week’s Clinical Correlations begins with email revelations implicating the administration of New Jersey Governor Chris Christie in the closure of traffic lanes across the George Washington Bridge, thus making one of the country’s busiest thoroughfares log-jammed with traffic for days this previous summer.

Earlier this week emails were released from high-level public servants in the Christie administration which suggest the secretive, planned closure of traffic lanes in the borough of Fort Lee, whose mayor had previously refused to…

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