Vancomycin Resistance in Staphylococcus Aureus: A Dangerous Dent in Our Armamentarium?

September 13, 2012
Vancomycin Resistance in Staphylococcus Aureus: A Dangerous Dent in Our Armamentarium?

By Bryan Stierman

Faculty Peer Reviewed

Staphylococcus aureus, first discovered in the 1880s, is one of the most widespread human pathogens. It is also a commensal organism, with about 20% of the population permanently colonized and 60% of the population intermittently colonized. There is a wide variety of potential diseases that may develop when S aureus further invades the body, necessitating the use of antibiotics. Since the introduction of antibiotics into clinical practice, S aureus has developed unique ways to combat them. The evolution of…

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Primecuts – This Week In The Journals

September 10, 2012
Primecuts – This Week In The Journals

By Anjali Varma Desai, M.D

Faculty Peer Reviewed

In the news this week, former US Open champion Andy Roddick ended his tennis career while Barack Obama sought to continue his presidential career. The Democratic National Convention, held last week in Charlotte, NC, featured speeches by President Obama and his wife, as well as former President Bill Clinton and Vice-President Joseph Biden. Many speeches addressed various aspects of Obama’s record, including his hotly-debated health care plan, with concrete references to the expected impact on the solvency…

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Fractional Excretion of Sodium (FENa): Diagnostic Godsend or Gimmick?

September 5, 2012
Fractional Excretion of Sodium (FENa): Diagnostic Godsend or Gimmick?

By Jon-Emile S Kenny, MD

Faculty Peer Reviwed

A 62- year-old man with a history of hypertension, diastolic dysfunction and chronic kidney disease is admitted 4 days after beginning outpatient treatment of community acquired pneumonia with cefpodoxime and azithromycin; he had been intermittently vomiting for two days, but proudly states that he has been keeping all of his home medications down, including hydrochlorothiazide. The morning after his admission, he was noted to have a serum creatinine of 3.4 mg/dL (from a baseline of 1.7 mg/dL).…

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Primecuts – This Week In The Journals

September 4, 2012
Primecuts – This Week In The Journals

By Devyani Kothari, MD

Faculty Peer Reviewed

In news this week, the Republic National Convention, which was held in Tampa, FL, concluded with speeches by Mitt Romney and Clint Eastwood. The final grand slam of the year, the US Open, headed into its second and final week in Flushing Meadows where Laura Robson, an 18-year-old from Britain sent Kim Clijsters into retirement after she defeated her in straight sets and Andy Roddick, also announced his retirement. Additionally, it’s hurricane season again as Hurricane Isaac hit…

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Are Dentists Really Causing Infective Endocarditis?

August 29, 2012
Are Dentists Really Causing Infective Endocarditis?

By Jeffrey Krutoy, DDS

Faculty Peer Reviewed

Bacterial infective endocarditis is a potentially devastating disease, and while it may be an easy tradition to blame the dentist, recent research and new guidelines from the American Heart Association (AHA) indicate that it may not be so simple.

 Infective endocarditis (IE), while relatively uncommon (with yearly incidence rates ranging from 2 to 6 cases per 100,000 people), results in high rates of morbidity and mortality even when treated. For this reason, physicians have emphasized the importance of…

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Primecuts – This Week In The Journals

August 27, 2012
Primecuts – This Week In The Journals

By Tracey Liebman, M.D.

Faculty Peer Reviewed

This week’s primecuts starts off with some other-worldly news . The NASA rover, known as Curiosity, had landed on Mars on August 6 after a 352-million-mile trip from earth. Finally, this week, Curiosity successfully made its first, albeit short, journey on Mars, going all of 23 feet. In the coming months and years, it will continue to take more journeys through the craters and mountains on Mars. With the intent of finding evidence that some form of life…

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Should We Measure Apolipoproteins to Evaluate Coronary Heart Disease Risk?

August 24, 2012
Should We Measure Apolipoproteins to Evaluate Coronary Heart Disease Risk?

By Navya Nair, MD

Faculty Peer Reviewed

Coronary heart disease (CHD) is the major cause of mortality worldwide. Lipoproteins play a major role in the development of this disease. Current guidelines advocate that low-density lipoprotein (LDL) cholesterol should be the primary target for lipid lowering therapy. However, there is a growing literature on the atherogenic potential of apolipoprotein B (apo B)-containing lipoproteins and the protective effect of apolipoprotein A-one (apo AI)-containing lipoproteins. Many studies suggest that these apolipoproteins be used as markers to evaluate risk…

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From The Archives: The Role of Serologic Testing in the Diagnosis of Celiac Disease

August 23, 2012
From The Archives: The Role of Serologic Testing in the Diagnosis of Celiac Disease

Please enjoy this post from the archives dated, August 18, 2010

By Todd Cutler

Faculty Peer Reviewed

A 31-year-old woman presents to the clinic with chronic fatigue. She was diagnosed with iron  deficiency anemia when she was 25 years old and has since taken oral contraceptives to limit bleeding during menstruation which she describes as minimal. She has a family history significant for an older brother with celiac disease. She is thin and her exam is significant for conjunctival pallor. Her laboratory findings are

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