By Benjamin Bearnot
Faculty Peer ReviewedÂ
Since the discovery of zidovudine (AZT) in the mid-1980s, advances in antiretroviral (ARV) therapy for patients with chronic human immunodeficiency virus (HIV) infection have, until recently, outpaced …
Category: Systems
Clinical Correlations
What is Sister Mary Joseph’s Nodule And Why Is It Significant?
September 15, 2011
By Keri Herzog, MD
Faculty Peer Reviewed
The patient is a 62-year-old male who presented to an outpatient medical clinic complaining of a growing, slightly painful, periumbilical mass, and mild lower gastrointestinal discomfort over the last 4 months. On examination, the …
Avastin and the Meaning of Evidence
September 9, 2011
By Antonella Surbone MD PhDÂ and Jerome Lowenstein MD
The recent hearings at the Food and Drug Administration regarding the revocation of approval for the use of Avastin in the treatment of breast cancer [1,2,3] bring into sharp focus several …
Should My Patient with a Solid Tumor be Anticoagulated in the Absence of Venous Thromboembolism?
September 8, 2011
By David Altszuler, Class of 2012
Faculty Peer Reviewed
An empiric association between occult malignancy and thrombophlebitis has been recognized since Trousseau first reported the syndrome in 1865.[1]Â The mechanism by which cancer predisposes to thrombophilia has not been fully elucidated; …
Should you Treat a COPD Exacerbation with Antibiotics?
September 3, 2011
By: Aviva Regev
Mr. S is a 68-year old man with longstanding COPD and a 40-pack-year smoking history. He presents to clinic with three days of increasing shortness of breath, and complains that he has been …
You Don’t Look Diabetic:Diabetes in Non-Obese South Asians–Is There a Molecular or Genetic Basis for Increased Insulin Resistance?
August 24, 2011
By Adelaide Hearst, MD
Faculty Peer Reviewed
Diabetes is a nationwide epidemic in the United States, affecting 23.6 million people, over 7% of the population.[1] But all diabetics may not be created equal. In the US, …
Subclinical Hypothyroidism: To Screen or Not to Screen?
August 17, 2011
By Addie Peretz, MD
Faculty Peer Reviewed
Despite the ease of screening for hypothyroidism with hormone assays and the availability of thyroxine replacement therapy, no recommendations regarding routine screening for hypothyroidism in adults are universally accepted. The American Academy of Family …
The Treatment For Clostridium Difficile? Transplant!
July 29, 2011
By Andrea Mignatti , MD
Faculty Peer Reviewed
Among all the new medical therapies, this one will probably not be the most elegant or refined that you will read about. But it …