Category: Pharmacology

Clinical Correlations

Clinical Pharmacy Corner: How Do Sulfonylureas Work?

Endocrine Pharmacology 2 min read

Commentary by Helen Kourlas, PharmD and John Papadopoulas, PharmD, Pharmacology Section Editors

The sulfonylureas are members of a class of substituted arylsulfonylureas that have been used clinically since the 1950s. These agents are usually divided into two categories or generations. First generation agents include acetohexamide, chlorpropamide, tolazamide, and tolbutamide (the …

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Clinical Pharmacy Corner: Sulfonamide Allergy and Cross-Reactivity

Pharmacology 4 min read

Commentary By Susan Morey PharmD, Pharmacy Practice Resident

Approximately 3% of patients who use sulfonamide antibiotics develop an allergic reaction, with the most common being the development of a maculopapular rash. (1, 2, 3) Sulfonamides are chemical compounds which contain a SO2NH2 moiety and can be divided into 3 …

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