By Gabrielle Mayer
Peer Reviewed
The patient’s bloodwork results seemed straight from a hematology textbook: low hemoglobin, low mean corpuscular volume, low ferritin, and high total iron binding capacity.1 The diagnosis appeared unambiguous: iron …
Category: Pharmacology
Clinical Correlations
Spotlight: A case of Metformin Associated Lactic Acidosis
May 11, 2018
By Jasmine Nee and Martin Fried, MD
Peer Reviewed
LEARNING OBJECTIVES
1. What is metformin-associated lactic acidosis?
2. How does severe acidemia lead to acute kidney injury?
3. How do you treat metformin-associated lactic acidosis?
CASE SUMMARY
The patient …
Insulin in a Pill: Barriers to Development of Oral Insulin
May 8, 2018
By Nicolas Gillingham
Peer Reviewed
Over 30 million Americans—9.4% of the population—live with diabetes, six million of whom are at least partially dependent on exogenous insulin.[1] Insulin can be self-administered by subcutaneous …
NSAIDs: Are They All the Same?
February 1, 2018
By Vishal Shah, MD
Peer Reviewed
Nonsteroidal antiinflammatory drugs (NSAIDs) are a heterogenous group of non-opioid analgesics and anti-inflammatory agents. Their use is ubiquitous, from treating a simple tension headache to a sprained ankle. NSAIDs are …
How Can You Best Address Polypharmacy in the Elderly?
December 21, 2017
By Michael Nguyen
Peer Reviewed
Polypharmacy has been defined as the use of multiple unnecessary medications, the use of more medications than is clinically warranted or indicated, or the use of unnecessary, …
Should Beta Blockers be Used in Heart Failure with Preserved Ejection Fraction?
August 23, 2017
By Lauren Christene Strazzulla
Peer Reviewed
The lifetime risk for developing heart failure from age 55 on is 33% for men and 28.5% for women, and as the population ages, there is an increasing prevalence of this …
The Forbidden Fruit
January 27, 2017
By Varun Narendra
Peer Reviewed
Griffith Hughes was the first to describe the grapefruit in 1750, naming it the “forbidden fruit” of Barbados for unknown reasons. Centuries later, it seems as if he may …
Gamechanger? Can Pioglitazone Reduce Cardiovascular Events After a Stroke? An Analysis of the IRIS Trial
January 19, 2017
By Johanna Hase, MD
Peer Reviewed
Welcome to Gamechangers, a series that takes a critical look at the latest in medical literature to answer one important question: would the results of this article …