By: Peter Lais
Peer Reviewed
A run-in period (“run-in”) is a pre-randomization phase in a randomized controlled trial (RCT) in which participants receive a placebo, investigational intervention, or other therapies to assess adherence, tolerability, and placebo responsiveness. Those who demonstrate nonadherence, intolerance of side …
By Felicia Ragucci
Peer Reviewed
My very first patient of clerkship year had the shortest medication list I’ll ever see: none. After confirming this, I asked if she takes over the counter …
By Martin Bouldo
Peer Reviewed
It is not uncommon for individuals to be concerned about where their food comes from. People want to know details like the “country of origin,” or if their eggs came …
By Joshua Wang
Peer Reviewed
Dan never imagined his nightly struggle with alcohol cravings might be cured with his diabetes medication. Yet, a few months after starting semaglutide for his blood …
By Olivia Descorbeth
Peer Reviewed
As individuals advance in age, they tend to accumulate medical conditions that require a bevy of pharmaceutical treatments to manage. As a result, polypharmacy, generally defined as the …
By Sarah M. Jackson
Peer Reviewed
During the COVID-19 pandemic, opioid overdose deaths increased from 50,000 in 2019 to 80,000 in 2021, largely driven by synthetic opioids such as fentanyl.1 Despite the escalating …
By Gabrielle Mayer
Peer Reviewed
The patient’s bloodwork results seemed straight from a hematology textbook: low hemoglobin, low mean corpuscular volume, low ferritin, and high total iron binding capacity.1 The diagnosis …
By Jasmine Nee and Martin Fried, MD
Peer Reviewed
LEARNING OBJECTIVES
1. What is metformin-associated lactic acidosis?
2. How does severe acidemia lead to acute kidney injury?
3. How do you treat metformin-associated lactic …