By Varun Narendra
Peer Reviewed
Griffith Hughes was the first to describe the grapefruit in 1750, naming it the “forbidden fruit” of Barbados for unknown reasons. Centuries later, it seems as if he may …
Category: Pharmacology
Clinical Correlations
Gamechanger? Can Pioglitazone Reduce Cardiovascular Events After a Stroke? An Analysis of the IRIS Trial
January 19, 2017
By Johanna Hase, MD
Peer Reviewed
Welcome to Gamechangers, a series that takes a critical look at the latest in medical literature to answer one important question: would the results of this …
Lies My Patients Told Me: “I Take My Medications Every Day.”
January 15, 2016
By Rebecca Sussman
Peer Reviewed
Reviewing medical evidence has become such a habit that sometimes it feels almost impossible to think independently. I’ve always been a top-down thinker; I go with my gut instinct, …
From The Archives: They’re all the ‘roid rage: origins and mechanisms of corticosteroid therapy.
April 3, 2014
Please enjoy this post from the archives dated September 23, 2011
By Santosh Vardhana, MD
A 36-year-old obese male with hypertension and hyperlipidemia presents to the ER with new knee pain, swelling, and erythema. Joint aspiration reveals negatively birefringent crystals. …
An antidote on the horizon? An update on the progress toward achieving reversibility for the new oral anticoagulants
February 21, 2014
By Gabriel Schneider, MD
Peer Reviewed
The new oral anticoagulants (NOACs) are an appealing alternative to the burdensome vitamin K antagonists such as warfarin. These novel agents include direct thrombin inhibitors such as dabigatran …
What Physicians Should Know About MDMA (Ecstasy)
February 20, 2014
By Loren Gorcey
Peer Reviewed
With the recent resurgence of techno music and raves in the United States, the drug MDMA, known worldwide by the name “ecstasy,” has experienced a comeback. In light …
From The Archives: The Polymyxins: Why am I using them all the time, and what are they?
November 21, 2013
Please enjoy this post from the archives dated December 8, 2010
By Jon-Emile S Kenny
Faculty Peer Reviewed
A 65-year-old female with locally advanced rectal cancer is admitted to the ICU, hypotensive and febrile. Her PICC line is removed and blood cultures …
FROM THE ARCHIVES – Kayexalate: What is it and does it work?
November 7, 2013
Please enjoy this post from the archives dated December 1, 2010
By Todd Cutler, MD
Faculty Peer Reviewed
A 62-year-old male is hospitalized with an acute congestive heart failure exacerbation. On hospital day three, the patient’s symptoms have significantly improved with twice daily furosemide …