Primecuts: This Week in the Journals

April 12, 2010
Primecuts: This Week in the Journals

Robert Gianotti, MD

Faculty Peer Reviewed

Welcome back to this week’s edition of prime cuts. For all you sports fans out there it has been filled with some exciting comebacks and breaking news. Earlier in the week, Duke was restored as the number one team in the nation as they edged out the Butler Bulldogs (61-59) to return to their former glory as the best in the NCAA. This week also marks the 74th Masters Golf Tournament featuring none other than Tiger Woods making his …

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Antimicrobial Therapy Geared at Pseudomonas aeruginosa for Bronchiectasis

April 7, 2010
Antimicrobial Therapy Geared at Pseudomonas aeruginosa for Bronchiectasis

Diana Hubulashvili, Pharm.D.

Edited by Tania Ahuja, Pharm.D., BCPS

Faculty peer reviewed

Bronchiectasis is an uncommon condition that is characterized by irreversible dilation of the bronchi. Chronic pulmonary infections and airway inflammation cause bronchial damage through destruction of the muscular and elastic layer of the bronchial wall leading to bronchiectasis. Bronchiectasis is associated with serious pulmonary infections, inflammation, chronic cough, and increased sputum production...

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PrimeCuts: This Week in the Journals

April 5, 2010
PrimeCuts: This Week in the Journals

Ankit Parikh MD

Faculty peer reviewed

It is time for the first Primecuts of April and the signs of spring are all around us. But before we spring forward into this edition of Primecuts, let us take a look back and reflect on “March Madness.” With all apologies to fans of Butler and Duke, this year “March Madness” was all about the historic battle for health care reform and passage of the Patient Protection and Affordable Care Act two weeks ago. In the face of …

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Breaking News: The Crestor Controversy

April 1, 2010
Breaking News: The Crestor Controversy

Devyani Kothari, MD

Patients are already talking about a New York Times front page article highlighting the risks associated with statin use as a preventive measure for cardiovascular events in relatively “healthy” people. The piece examines the newest FDA indications for the use of Crestor along with the controversies surrounding the drug.

Last month, the FDA approved Rosuvastatin Calcium, marketed as Crestor by AstraZeneca for use in a new patient population , based on the JUPITER trial. Crestor now carries the indication for the primary …

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How Easily is Tuberculosis Spread?

March 31, 2010
How Easily is Tuberculosis Spread?

Molly Cason

Faculty peer reviewed

In a city of over 8 million people, New York City has an annual tuberculosis case rate of 11.4 per 100,000 people, which is more than twice the national average.  Seventy-one percent of these cases occur in people who were born outside the United States.1 As a student, I had a patient (Y) who was being evaluated for active tuberculosis because he is a household contact of a person (X) known to have active multi-drug resistant tuberculosis. I wondered what …

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Primecuts-This Week in the Journals

March 29, 2010
Primecuts-This Week in the Journals

Kara Greenwald, MD

Faculty Peer Reviewed

The United States medical community, still reeling from an exciting debate in Congress, has revealed its cautiously optimistic side this week in the journals and press.  At once there is exciting news for liver disease,  a fresh look at the proton pump inhibitor (PPI) – clopidogrel interaction, an update on global MDR-TB and XDR-TB, and from the FDA some news that may surprise you. The theme in medical news this week is “moving forward with an eye on the …

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Mystery Quiz- The Answer

March 28, 2010
Mystery Quiz- The Answer

Vivian Hayashi MD and Robert Smith MD, Mystery Quiz Section Editors

The answer to the mystery quiz is progressive massive fibrosis. This condition is a severe form of silicosis. The chest radiograph (Image 3) shows bullous disease of the right upper lobe, increased density of the right hilum, increased density and upward retraction of the left hilum (also seen in Image 4), increased density in peripheral areas of both lungs, and an air crescent sign in the left upper lobe (also seen in Image 5). …

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The Evolution of Cardiac Biomarkers: What’s on the Horizon?

March 24, 2010
The Evolution of Cardiac Biomarkers:  What’s on the Horizon?

Rushi Parikh

Faculty peer reviewed

Cardiac biomarkers have historically been a mainstay of the diagnostic criteria of acute coronary syndrome (ACS). Previously utilized cardiac biomarkers include aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and myoglobin; now more often troponin and to a lesser extent creatine kinase-MB are the principal biomarkers used to diagnose ACS.1

Myocardial necrosis and the subsequent loss of cardiomyocyte membrane integrity lead to the release of cardiac biomarkers into the peripheral circulation. Biomarkers, however, do not indicate the cause of myocardial necrosis, and …

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