Shotrcuts-This Week in the Journals

December 17, 2007
Shotrcuts-This Week in the Journals

Commentary By: Neil Shapiro, M.D., Editor-In-Chief, Clinical Correlations

It’s hard to believe there was other news this week besides the black cloud that has now been cast over all of baseball.  Barry Bonds must be smiling somewhere knowing that others have now climbed aboard his sinking ship…in fact I had a dream last night that the Yankees were even stripped of their 2000 World Series title just like all those cheating olympic athletes and the title of 2000 World Champions was awarded to the World…

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FDA Warns of Possible Link Between Chantix Therapy and Mood Disturbances

December 14, 2007
FDA Warns of Possible Link Between Chantix Therapy and Mood Disturbances

Commentary by Robert Leonard PharmD, Pharmacy Resident New York Harbor Healthcare System

On November 20, 2007 the FDA announced mounting evidence linking varenicline (Chantix®) therapy for smoking cessation with suicidal ideation and erratic and aggressive behavior. The announcement comes in response to post-marketing case reports submitted to the FDA by the makers of Chantix®, Pfizer Inc. Early review of the cases reveal new onset of depressed mood, suicidal thoughts, and changes in emotions or behaviors within days to weeks of starting Chantix® therapy. A direct…

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Meeting Perspectives: Annual Meeting of the Infectious Diseases Society of America (IDSA) October, 2007

December 13, 2007
Meeting Perspectives: Annual Meeting of the Infectious Diseases Society of America (IDSA)  October, 2007

Commentary by Neal Steigbigel MD, Professor of Medicine (Infectious Diseases/Immunology)

Methicillin resistant Staphylococcus aureus (MRSA) was a hot topic at this year’s IDSA meeting. The CA (community-acquired)-MRSA strains are spreading rapidly in the United States causing largely soft tissue infections, but also other infections such as serious necrotizing pneumonia. Clinicians can no longer rely on demographics in predicting which patient is at high risk for MRSA when an individual appears with a suspected staph infection. If the infection appears serious and is…

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ShortCuts-This Week in the Journals

December 12, 2007
ShortCuts-This Week in the Journals

Commentary By: Sean Cavanaugh, M.D. Associate Editor Clinical Correlations

Science magazine published the first practical application of the induced pluripotent stem (IPS) cells in a mouse model for sickle cell anemia. As was recently published, skin cells can be transformed into pluripotent cells by the insertion of genes Oct4, Sox2, Lif4 and c-Myc, known to act together as master regulators, to keep cells in an embryonic stem cell-like state. In this experiment, gene specific targeting of these cells corrected the sickle cell gene…

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Grand Rounds-”The Joys of Translational Research”

December 11, 2007
Grand Rounds-”The Joys of Translational Research”

Commentary By: Benjamin Bergman PGY-2

This week’s Grand Rounds lecture was delivered by Dr. Barry Coller, a graduate of our own internal medicine program in 1972. He completed advanced training in hematology and clinical pathology at the National Institutes of Health and is currently the David Rockefeller Professor of Medicine, Head of the Laboratory of Blood and Vascular Biology, and Physician-in-Chief of The Rockefeller University Hospital. Dr. Coller’s research interests have focused on hemostasis and thrombosis, in particular platelet physiology.  He developed a…

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Ethical Dilemmas: Artificial Feeding

December 7, 2007
Ethical Dilemmas: Artificial Feeding

Commentary by Shrujal Baxi MD, Ethics Section Editor, and Joseph Lowy MD, Medical Director, Palliative Care Service at NYU Hospital

Mrs. Pleasant is an 85 year old woman brought into the ER by her son for poor appetite. Mrs. P is demented secondary to progressive Alzheimer’s disease and has had 3 hospitalizations in the last year for pneumonia, possibly related to aspiration.  Upon physical exam, she is oriented to herself, but is unable to provide any other information. She denies pain and appears to be…

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Clinical Pathology Conference 12/7/07

December 5, 2007
Clinical Pathology Conference 12/7/07

Case presentation by Alana Choy-Shan MD, Chief Resident

Welcome to the monthly posting of our NYU Department of Medicine’s Clinical Pathology Conference. Use the links below to review the case and the radiological findings. Our faculty and medical students will be attempting to diagnose this unknown case Friday 12/7/07 in the 17 West Conference Room at Bellevue Hospital. Feel free to make your diagnosis by clicking the comment field below. For those who are unable to attend the live conference, we will reveal…

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Grand Rounds: “Innate Immunity and Viral Pathogenesis”

December 4, 2007
Grand Rounds: “Innate Immunity and Viral Pathogenesis”

Commentary by Urania Rappo, PGY-2

This week’s Medicine Grand Rounds guest lecturer was Dr. Robert Finberg, currently Chair of the Department of Medicine at the University of Massachusetts Medical School. He earned his MD from Albert Einstein College of Medicine and trained in Medicine at Bellevue Hospital starting in 1974. He was a Fellow in Infectious Diseases at Harvard Medical School, and there established a rich research career over the ensuing twenty years. Dr. Finberg’s research focuses on host-microbial interactions, defining the cell surface proteins…

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