An Update on Multiple Sclerosis

August 21, 2007
An Update on Multiple Sclerosis

Commentary by Jacqueline Friedman, MD, Clinical Associate Professor of Neurology,  Director, New York Region Veterans Administration Multiple Sclerosis Center of Excellence

Multiple sclerosis (MS), a chronic disease of the central nervous system, is thought to be initiated by an inflammatory phase followed by degeneration of both white and grey matter. While there is no cure, great strides have been made in the past ten years—we now believe that the earlier a diagnosis is suspected and treatment is initiated, the better the long-term course…

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Shortcuts-This Week in the Journals

August 20, 2007
Shortcuts-This Week in the Journals

Commentary By: Neil Shapiro, M.D. Editor-in-Chief Clinical Correlations

As summer winds down and the weather prematurely cools off, this weeks shortcuts finds us focusing on the genetics of coumadin treatment, the very controversial hpv vaccine, and the evils of direct to consumer advertising, and to keep us clean we conclude with a bit about antibacterial soaps and what else you can find at your local drugstore…

The front page of the wall street journal picked up an FDA medwatch advisory approving labeling…

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Reemergence of the Great Imitator: Overview of the Diagnosis and Treatment of Syphilis

August 17, 2007
Reemergence of the Great Imitator: Overview of the Diagnosis and Treatment of Syphilis

Commentary by Rosemary Adamson, PGY2,  Deena Altman PGY-1 and Harold Horowitz, Professor of Medicine, Section of Infectious Diseases 

Syphilis is back! You know the drill: an 80-something year old man presents with dementia and you send the TSH, B12 and RPR and get a head CT, all the while expecting some microvascular disease & age-related cortical volume loss. Imagine my surprise when my VA patient had a positive RPR and then the lumbar puncture returned a positive VDRL. To be fair, he wasn’t…

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Clinical Pathology Conference 8/16/07

August 16, 2007
Clinical Pathology Conference 8/16/07

Case Presentation By: Marshall Fordyce, Senior Chief Resident

Welcome to the monthly posting of our NYU Department of Medicine’s Clinical Pathology Conference. Use the links below to review the case and the radiological findings. Our faculty and medical students will be attempting to diagnose this unknown case Friday 8/16/07 in the 17 West Conference Room at Bellevue Hospital. Feel free to make your diagnosis by clicking the comment field below. For those who are unable to attend the live conference, we will reveal…

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Clinical Pharmacology Corner: Beta-Adrenergic Receptors Antagonists

August 14, 2007
Clinical Pharmacology Corner:  Beta-Adrenergic Receptors Antagonists

Commentary by Helen Kourlas, PharmD

Beta-adrenergic receptor antagonists, commonly known as beta-blockers (B-blockers) have been used for decades to treat hypertension, ischemic heart disease and some arrhythmias – and more recently to treat congestive heart failure. (1,2) Typically, B receptors are located in the heart (B1) and in peripheral vessels (B2) and the binding of catecholamines (epinephrine, norepinephrine and dopamine) to B1 receptors produce positive chronotropic and inotropic effects, while the binding of the B2 receptors produce a vasodilatory response in the peripheral…

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Shortcuts-This Week in the Journals

August 13, 2007
Shortcuts-This Week in the Journals

Commentary By Sean Cavanaugh, M.D. Associate Editor, Clinical Correlations

With the ever-increasing public concern about drug safety, and the profusion of wave-making research into clinical endpoints, occasional very public collisions are inevitable. And so opens this week’s Shortcuts…

Two recent seemingly opposing results were published in the past few weeks concerning the effects of statin therapy on patients with low LDL. Circulation featured a study looking at the safety and clinical outcomes associated with statin therapy in patients with very low LDL…

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Health Care Reform: An Overview of Recent Proposals

August 9, 2007
Health Care Reform: An Overview of Recent Proposals

Commentary by Zackary Berger MD PhD, PGY-2 

In the political arena, reforming health care is continually a major domestic issue. It’s no surprise that the lead 2008 democratic contenders cite the same statistic on each of their websites, “Nearly 45 million Americans, including 9 million children, are without health insurance.” Moreover, on each of their sites, the candidates ambitiously describe plans that would provide universal and affordable healthcare for all Americans. Their tactics largely entail expanding Medicaid, holding employers more accountable to providing…

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Part II- Subclinical Thyroid Dysfunction: To Treat or Not to Treat?

August 8, 2007
Part II- Subclinical Thyroid Dysfunction: To Treat or Not to Treat?

Commentary by Melissa Freeman MD, PGY2

Please also see Part I of this series

In 2002, the American Association of Clinical Endocrinologists (AACE), the American Thyroid Association (ATA), and The Endocrine Society (TES) sponsored an evidence- based Consensus Development Conference with a panel of thirteen experts to address unresolved issues about subclinical thyroid dysfunction. Though these sponsors agreed with many of the recommendations made by the consensus, they felt that they relied too heavily on evidence-based medicine that did not yet exist. Two years later,…

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